When I grew up with computers, the big RISC vs CISC debate was raging. At the time, in the late 1980s, it did indeed seem that RISC was inherently superior to CISC. SPARCs, MIPS, and Alpha all outpaced boring old x86, VAX and 68000 processors. This turned out to be a historical parenthesis, as the Pentium Pro from Intel showed how RISC-style performance could be mated to a CISC ISA. However, maybe ISAs still do matter.
There is a new post at my Wind River blog, telling the story of how some of the Simics developers used Simics itself to debug an intermittent Simics program crash caused by a timing-sensitive race condition.
Running Simics on itself is pretty cool, and shows the power of the simulator and its applicability even to really complex software.